21 C.F.R. § 558.311 Lasalocid.
Title 21 - Food and Drugs
(a) Specifications. A minimum of 90 percent of lasalocid activity is derived from lasalocid A. (b) Approvals. Type A medicated articles approved for sponsors identified in §510.600(c) of this chapter for use as in paragraph (e) of this section as follows: (1) 3.0, 3.3, 3.8, 4.0, 4.3, 4.4, 5.0, 5.1, 5.5, 5.7, 6.0, 6.3, 6.7, 7.2, 7.5, 8.0, 8.3, 10.0, 12.5, 15, 20, and 50 percent activity to No. 046573 for use as in paragraphs (e)(1) (i), (ii), (iii), (iv), and (x) of this section. (2) 15 percent activity to No. 066104 as provided by No. 046573 for use as in paragraph (e)(1)(v) of this section. (3) 15, 20, 33.1, and 50 percent activity to No. 046573 for use in cattle feeds as in paragraphs (e)(1)(vi), (vii), (ix), (xi), (xii), and (xv) of this section, and for use in sheep as in paragraph (e)(1)(viii) of this section. (4) 15 percent activity to No. 046573 for use in Type C rabbit feeds as in paragraph (e)(1)(xvi) of this section and for use in ruminant free-choice Type C feeds as in paragraphs (e)(2), (e)(3), and (e)(4) of this section. (5) 15 percent activity to 021930 (Type A article provided by 046573) for use in free-choice vitamin-mineral Type C cattle feeds as in paragraph (e)(1)(xi). (6) 20 percent activity as a liquid Type A article to No. 046573 for use in cattle feeds as in paragraphs (e)(1)(vi), (e)(1)(vii), (e)(1)(ix), (e)(1)(xi), (e)(1)(xii), and (e)(3) of this section, and for use in sheep feeds as in paragraph (e)(1)(viii) of this section. (7) 20 percent activity to No. 046573 for use as follows: (i) Chukar partridges as in paragraph (e)(1)(xiii). (ii) Turkeys as in paragraph (e)(1)(xiv). (iii) Rabbits as in paragraph (e)(1)(xvi). (8) 15 percent activity to No. 017800 for use as in paragraph (e)(1)(xviii) of this section. (9) 15 percent activity to No. 068287 for use in free-choice protein blocks for cattle as in paragraphs (e)(1)(xix) of this section. (c) Related tolerance. See §556.347 of this chapter. (d) Special considerations. (1) Type C cattle and sheep feeds may be manufactured from lasalocid liquid Type B feeds which have a pH of 4.0 to 8.0 and bear appropriate mixing directions as follows: (i) For liquid feeds stored in recirculating tank systems: Recirculate immediately prior to use for no less than 10 minutes, moving not less than 1 percent of the tank contents per minute from the bottom of the tank to the top. Recirculate daily as described even when not used. (ii) For liquid feeds stored in mechanical, air, or other agitation-type tank systems: Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily as described even when not used. (2) A physically stable lasalocid liquid feed will not be subject to the requirements for mixing directions prescribed in paragraph (d)(1) of this section provided it has a pH of 4.0 to 8.0 and contains a suspending agent(s) sufficient to maintain a viscosity of not less than 300 centipoises per second for 3 months. (3) If a manufacturer is unable to meet the requirements of paragraph (d)(1) or (d)(2) of this section, the manufacturer may secure approval of a positionally stable liquid feed by: (i) Either filing a new animal drug application for the product or establishing a master file containing data to support the stability of its product; (ii) Authorizing the agency to reference and rely upon the data in the master file to support approval of a supplemental new animal drug application to establish physical stability; and (iii) Requesting the sponsor of an approved new animal drug application to file a supplement to provide for use of its lasalocid Type A article in the manufacture of the liquid feed specified in the appropriate master file. If the data demonstrate the stability of the liquid feed described in the master file, the supplemental new animal drug application will be approved. The approval will provide a basis for the individual liquid feed manufacturer to manufacture under a medicated feed license the liquid mediated feed described in the master file. A manufacturer who seeks to market a physically unstable lasalocid liquid feed with mixing directions different from the standard directions established in paragraph (d)(1) of this section may also follow this procedure. (4) If adequate information is submitted to show that a particular liquid feed containing lasalocid is stable outside the pH of 4.0 to 8.0, the pH restriction described in paragraphs (d)(1) and (d)(2) of this section may be waived. (5) Required label statements: (i) For liquid Type B feed (cattle and sheep): Mix thoroughly with grain and/or roughage prior to feeding. Feeding undiluted, mixing errors, or inadequate mixing (recirculation or agitation) may result in an excess lasalocid concentration which could be fatal to cattle and sheep. Do not allow horses or other equines access to Type A articles or Type B feeds containing lasalocid as ingestion may be fatal. Safety of lasalocid for use in unapproved species has not been established. (ii) For Type A articles or Type B feeds (cattle and sheep): Feeding undiluted or mixing errors may result in an excess lasalocid concentration which could be fatal to cattle and sheep. Do not allow horses or other equines access to Type A articles or Type B feeds containing lasalocid as ingestion may be fatal. Safety of lasalocid for use in unapproved species has not been established. (iii) For Type A articles, Type B or Type C feeds (cattle): A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal. (6) Lasalocid Type A medicated articles containing lasalocid dried fermentation residue are for use in cattle and sheep feed only. (7) Each use in a free-choice Type C cattle feed as in paragraphs (e)(1)(xii) and (e)(1)(xviii) of this section must be the subject of an approved NADA or supplemental NADA as provided in §510.455 of this chapter. (e)(1) Conditions of use. It is used as follows: (2) It is used as a free-choice mineral Type C feed as follows: (i) Specifications. (ii) Amount. 1,440 grams per ton (0.16 percent). (iii) Indications for use. Pasture cattle (slaughter, stocker, feeder cattle, and dairy and beef replacement heifers): for increased rate of weight gain. Intakes of lasalocid in excess of 200 mg/head/day have not been shown to be more effective than 200 mg/head/day. (iv) Limitations. For pasture cattle (slaughter, stocker, feeder cattle, and dairy and beef replacement heifers); feed continuously on a free-choice basis at a rate of 60 to 300 milligrams lasalocid per head per day. (v) Sponsor. See No. 046573 in §510.600(c) of this chapter. (3) It is used as a ruminant free-choice liquid Type C feed as follows: (i) Specifications. (ii) Amount. 150 grams per ton (.017 percent). (iii) Indications for use. Pasture cattle (slaughter, stocker, feeder cattle, and dairy and beef replacement heifers): for increased rate of weight gain. Intakes of lasalocid in excess of 200 mg/head/day have not been shown to be more effective than 200 mg/head/day. (iv) Limitations. For pasture cattle (slaughter, stocker, feeder cattle, and dairy and beef replacement heifers). Feed continuously on a free-choice basis at a rate of 60 to 300 milligrams lasalocid per head per day. (v) Sponsor. See No. 046573 in §510.600(c) of this chapter. (4) It is used as a free-choice, loose mineral Type C feed as follows: (i) Specifications. (ii) Amount. 1,088 grams per ton. (iii) Indications for use. Pasture cattle (slaughter, stocker, feeder cattle, and dairy and beef replacement heifers): For increased rate of weight gain. Intakes of lasalocid in excess of 200 mg/head/day have not been shown to be more effective than 200 mg/head/day. (iv) Limitations. Feed continuously on a free-choice basis at a rate of 60 to 300 mg lasalocid per head per day. (v) Sponsor. See No. 046573 in §510.600(c) of this chapter. (5) Additional combinations. Lasalocid may be used in accordance with the provisions of this section in combination as follows: (i) Melengestrol acetate alone or in combination with tylosin in accordance with §558.342. (ii) [Reserved] [41 FR 44382, Oct. 8, 1976] Editorial Note: For
Title 21: Food and Drugs
PART 558—NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS
Subpart B—Specific New Animal Drugs for Use in Animal Feeds
§ 558.311 Lasalocid.
---------------------------------------------------------------------------------------------------------------- Lasalocid sodium activity in Combination in grams grams per ton per ton Indications for use Limitations Sponsor----------------------------------------------------------------------------------------------------------------(i) 68 (0.0075 pct) to 113 .................... For the prevention of For broiler or 046573 (0.0125 pct). coccidiosis caused by fryer chickens Eimeria tenella, E. only; feed necatrix, E. continuously as acervulina, E. the sole ration. brunetti, E. mivati, and E. maxima.(ii) 68 (0.0075 pct) to 113 Roxarsone 45.4 Broiler or fryer For broiler or 046573 (0.0125 pct). (0.005 pct). chickens; for the fryer chickens prevention of only; feed coccidiosis caused by continuously as Eimeria tenella, E. the sole ration; necatrix, E. as sole source of acervulina, E. organic arsenic; brunetti, E. mivati, withdraw 5 d and E. maxima and as before slaughter; an aid in the roxarsone provided reduction of lesions by Nos. 046573 and due to E. tenella. 011526 in § 510.600(c) of this chapter. Roxarsone 45.4 plus For prevention of For broiler 046573 bambermycins 1 coccidiosis caused by chickens only; (0.00011 pct). Eimeria tenella, E. feed continuously necatrix, E. as sole ration; acervulina, E. withdraw 5 days brunetti, E. mivati, before slaughter; and E. maxima; as an roxarsone provided aid in the reduction by Nos. 046573 and of lesions due to E. 011526 in § tenella; and for 510.600(c) of this increased rate of chapter, weight gain. bambermycins provided by No. 016592. Bambermycins 1 to 2. Broiler chickens: For Feed continuously 016592 prevention of as sole ration. coccidiosis caused by Bambermycins Eimeria tenella, E. provided by No. necatrix, E. 016592 in § acervulina, E. 510.600(c) of this brunetti, E. mivati, chapter.. and E. maxima; and for increased rate of weight gain and improved feed efficiency.. Roxarsone 45.4 plus For prevention of For broiler 046573 lincomycin 2.0. coccidiosis caused by chickens only; Eimeria tenella, E. feed continuously necatrix, E. as sole ration; acervulina, E. withdraw 5 days brunetti, E. mivati, before slaughter; and E. maxima; as an roxarsone provided aid in the reduction by Nos. 046573 and of lesions due to E. 011526 in § tenella; and for 510.600(c) of this increased rate of chapter, weight gain and lincomycin improved feed provided by No. efficiency. 000009. Roxarsone 45.4 plus For prevention of For broiler or 046573 bacitracin 10 to 25. coccidiosis caused by fryer chickens Eimeria tenella, E. only; feed necatrix, E. continuously as acervulina, E. the sole ration; brunetti, E. mivati, withdraw 5 days and E. maxima; as an before slaughter; aid in the reduction roxarsone provided of lesions due to E. by Nos. 046573 and tenella; and for 011526 in § increased rate of 510.600(c) of this weight gain. chapter, bacitracin methylene disalicylate provided by No. 046573 in § 510.600(c) of this chapter. Roxarsone 45.4 plus For prevention of For broiler 046573 bacitracin 10 or 30. coccidiosis caused by chickens only; E. tenella, E. feed continuously necatrix, E. as sole ration; acervulina, E. withdraw 5 days brunetti, E. mivati before slaughter; and E. maxima; as an roxarsone provided aid in the reduction by Nos. 046573 and of lesions due to E. 011526 in § tenella; and for 510.600(c) of this increased rate of chapter, weight gain (10 grams bacitracin zinc per ton) or improved provided by No. feed efficiency (30 000004. grams per ton). Roxarsone 45.5 plus Prevention of Feed continuously 046573 bacitracin coccidiosis caused by as sole ration; as methylene Eimeria necatrix, E. sole source of disalicylate 50. tenella, E. organic arsenic; acervulina, E. withdraw 5 days brunetti; E. mivati, before slaughter. and E. maxima; reduction of lesions due to E. tenella; prevention of necrotic enteritis caused or complicated by Clostridium spp. or other susceptible organisms.(iii) 68 (0.0075 pct)............ Lincomycin 2 Broiler or fryer For broiler and 046573 (0.00022 pct). chickens; for the fryer chickens prevention of only; feed coccidiosis caused by continuously as Eimeria mivati, E. sole ration; brunetti, E. tenella, withdraw 5 d E. acervulina, E. before slaughter; maxima, and E. Type C feed must necatrix; for be used within 4 increased rate of weeks of weight gain and manufacture; as improved feed lincomycin efficiency. hydrochloride monohydrate.(iv) 68 (0.0075 percent)......... Bacitracin 10 to 50. For prevention of For broiler or 046573 coccidiosis caused by fryer chickens Eimeria tenella, E. only; feed necatrix, E. continuously as acervulina, E. the sole ration; brunetti, E. mivati, bacitracin and E. maxima, and for methylene increased rate of disalicylate weight gain and provided by No. improved feed 046573 in § efficiency. 510.600(c) of this chapter.(v) 68 (0.0075 pct) to 113 Virginiamycin 20.... For prevention of For broiler and 046573 (0.0125 pct). coccidiosis caused by fryer chickens Eimeria tenella E. only; feed necatrix, E. continuously as acervulina, E. sole ration; do brunetti, E. mivati, not feed to laying and E. maxima, and for chickens; increased rate of lasalocid sodium weight gain and provided by No. improved feed 046573 in § efficiency. 510.600(c) of this chapter.(vi) 10 (0.0011 pct) to 30 .................... Cattle; for improved In Type C feeds; 046573 (0.0033 pct). feed efficiency. for cattle fed in confinement for slaughter only; feed continuously in complete feed to provide not less than 100 mg nor more than 360 mg of lasalocid sodium activity per head per day. Oxytetracycline 7.5. Cattle: for improved In Type C feeds, 046573 feed efficiency and for beef cattle reduction of incidence fed in confinement and severity of liver for slaughter; abscesses. feed continuously at 100 to 360 mg/ head/day lasalocid and 75 mg/head/day oxytetracycline. As monoalkyl (C8- C18) trimethyl ammonium oxytetracycline.(vii) 25 (0.0027 pct) to 30 .................... Cattle; for improved In Type C feeds; 046573 (0.0033 pct). feed efficiency and for cattle fed in increased rate of confinement for weight gain. slaughter only; feed continuously in complete feed to provide not less than 250 mg nor more than 360 mg of lasalocid sodium activity per head per day. Oxytetracycline 7.5. Cattle: for improved In Type C feeds, 046573 feed efficiency, for beef cattle increased rate of fed in confinement weight gain, and for slaughter; reduction of incidence feed continuously and severity of liver at 250 to 360 mg/ abscesses. head/day lasalocid and 75 mg/head/day oxytetracycline. As monoalkyl (C8- C18) trimethyl ammonium oxytetracycline.(viii) 20 (0.0022 pct) to 30 .................... Sheep; for the In Type C feeds; 046573 (0.0033 pct). prevention of for sheep coccidiosis caused by maintained in Eimeria ovina, E. confinement; feed crandallis, E. continuously in ovinoidalis (E. complete feed to ninakohlyakimovae), E. provide not less parva, and E. than 15 mg nor intricata. more than 70 mg of lasalocid sodium activity per head per day depending on body weight.(ix)............................. .................... Pasture cattle Feed continuously 046573 (slaughter, stocker, at a rate of not feeder cattle, and less than 60 mg or dairy and beef more than 300 mg replacement heifers): of lasalocid per for increased rate of head per day when weight gain. Intakes on pasture; the of lasalocid in excess drug must be of 200 mg/head/day contained in at have not been shown to least 1 pound of be more effective than feed.. 200 mg/head/day..(x) 68 (0.0075 pct) to 113 Bacitracin 4 to 50.. Broiler chickens; for For broiler 046573 (0.0125 pct). prevention of chickens only; coccidiosis caused by feed continuously Eimeria tenella, E. as the sole necatrix, E. ration; bacitracin acervulina, E. methylene brunetti, E. mivati, disalicylate and E. maxima; and for provided by No. improved feed 046573 in § efficiency. 510.600(c) of this chapter.(xi) 68 (0.0075 pct) to 113 Bacitracin zinc 4 to Broiler chickens. For Feed continuously 046573 (0.0125 pct). 50. prevention of as sole ration. coccidiosis caused by Bacitracin zinc Eimeria tenella, E. and lasalocid necatrix, E. sodium as provided acervulina, E. by No. 046573 in brunetti, E. mivati, § 510.600(c) and E. maxima, and for of this chapter.. increased rate of weight gain and improved feed efficiency..(xii)............................ .................... Pasture cattle Feed continuously 046573 (slaughter, stocker, on a free-choice feeder cattle, and basis at a rate of dairy and beef not less than 60 replacement heifers): mg or more than For increased rate of 300 mg of weight gain. Intakes lasalocid per head of lasalocid in excess per day.. of 200 mg/head/day have not been shown to be more effective than 200 mg/head/day..(xiii)........................... .................... Cattle; for control of For cattle; hand 046573 coccidiosis caused by feed at a rate of Eimeria bovis and 1 mg of lasalocid Eimeria zuernii. per 2.2 pounds body weight per day to cattle weighing up to 800 pounds with a maximum of 360 mg of lasalocid per head per day.(xiv) 113 (0.0125 pct)........... .................... Chukar partridges; for Feed continuously 046573 prevention of as sole ration up coccidiosis caused by to 8 weeks of age. Eimeria legionensis.(xv) 68 (0.0075 pct) to 113 .................... Growing turkeys; for Feed continuously 046573 (0.0125 pct). prevention of as sole ration. coccidiosis caused by E. meleagrimitis, E. gallopavonis, and E. adenoeides.. Bacitracin 4 to 50.. Growing turkeys; for Feed continuously 046573 prevention of as sole ration. coccidiosis caused by E. meleagrimitis, E. gallopavonis, and E. adenoeides; for increased rate of weight gain and improved feed efficiency.. Bacitracin methylene Growing turkeys; for Feed continuously 046573 disalicylate 4 to prevention of as sole ration. 50. coccidiosis caused by Bacitracin E. meleagrimitis, E. methylene gallopavonis, and E. disalicylate as adenoeides; for provided by No. increased rate of 046573 in § weight gain and 510.600(c) of this improved feed chapter.. efficiency.. Virginiamycin 10 to Growing turkeys; for Feed continuously 046573 20. prevention of as sole ration. As coccidiosis caused by lasalocid sodium E. meleagrimitis, E. provided by 063238 gallopavonis, and E. and virginiamycin adenoeides, and for provided by increased rate of 066104.. weight gain and improved feed efficiency..(xvi)............................ .................... Replacement calves; for In milk replacer 046573 control of coccidiosis powder; hand feed caused by E. bovis and at a rate of 1 mg E. zuernii.. of lasalocid per 2.2 lb body weight per day; include on labeling warning: ``A withdrawal period has not been established for lasalocid in pre- ruminating calves. Do not use in calves to be processed for veal''.(xvii) 113 (0.0125 pct).......... .................... Rabbits; for prevention Feed continuously 046573 of coccidiosis caused as sole ration up by Eimeria stiedae. to 6 1/2 weeks of age.(xviii) 1440..................... .................... Pasture cattle Feed continuously 021930 (slaughter, stocker, on a free-choice 017800 feeder cattle, and basis at a rate of dairy and beef not less than 60 replacement heifers): mg nor more than For increased rate of 200 mg of weight gain.. lasalocid per head per day..(xix) 300........................ .................... Pasture cattle Feed continuously 068287 (slaughter, stocker, on a free-choice feeder cattle, and basis at a rate of dairy and beef not less than 60 replacement heifers): mg nor more than for increased rate of 200 mg of weight gain.. lasalocid per head per day..(xx) 10 to 30.................... Chlortetracycline 25 1. Cattle fed in Feed continuously 046573 to 100. confinement for in complete feed slaughter: For at a rate of 350 improved feed mg efficiency; and for chlortetracycline control of bacterial and not less than pneumonia associated 100 mg nor more with shipping fever than 360 mg of complex caused by lasalocid sodium Pasteurella spp. activity per head susceptible to per day.. chlortetracycline.. .................... 2. Cattle under 700 Feed continuously 046573 pounds fed in in complete feed confinement for at a rate of 350 slaughter: For mg improved feed chlortetracycline efficiency; and for and not less than control of active 100 mg nor more infection of than 360 mg of anaplasmosis caused by lasalocid sodium Anaplasma marginale activity per head susceptible to per day.. chlortetracycline..(xxi) 10 to 30................... Chlortetracycline Cattle fed in Feed continuously 046573 500 to 2000. confinement for in complete feed slaughter: For for not more than improved feed 5 days to provide efficiency; and for 10 mg treatment of bacterial chlortetracycline enteritis caused by E. per lb body weight coli and bacterial per day and not pneumonia caused by P. less than 100 mg multocida organisms nor more than 360 susceptible to mg of lasalocid chlortetracycline.. sodium activity per head per day..(xxii) 25 to 30.................. Chlortetracycline 25 1. Cattle fed in Feed continuously 046573 to 42.2. confinement for in complete feed slaughter: For at a rate of 350 increased rate of mg weight gain and chlortetracycline improved feed and not less than efficiency; and for 250 mg nor more control of bacterial than 360 mg of pneumonia associated lasalocid sodium with shipping fever activity per head complex caused by per day.. Pasteurella spp. susceptible to chlortetracycline.. .................... 2. Cattle under 700 Feed continuously 046573 pounds fed in in complete feed confinement for at a rate of 350 slaughter: For mg increased rate of chlortetracycline weight gain and and not less than improved feed 250 mg nor more efficiency; and for than 360 mg of control of active lasalocid sodium infection of activity per head anaplasmosis caused by per day.. Anaplasma marginale susceptible to chlortetracycline..(xxiii) 25 to 30................. Chlortetracycline Cattle fed in Feed continuously 046573 500 to 1200. confinement for in complete feed slaughter: For for not more than increased rate of 5 days to provide weight gain and 10 mg improved feed chlortetracycline efficiency; and for per lb body weight treatment of bacterial per day and not enteritis caused by E. less than 250 mg coli and bacterial nor more than 360 pneumonia caused by P. mg of lasalocid multocida organisms sodium activity susceptible to per head per day.. chlortetracycline..(xxiv) 30 to 181.8............... Chlortetracycline 25 1. Beef cattle under Hand feed 046573 to 2800. 700 pounds: For continuously at a control of coccidiosis rate of 350 mg caused by Eimeria chlortetracycline bovis and E. zuernii; per head per day and for control of and 1 mg lasalocid active infection of per 2.2 lb body anaplasmosis caused by weight per day Anaplasma marginale with a maximum of susceptible to 360 mg lasalocid chlortetracycline.. per head per day.. .................... 2. Beef cattle up to Hand feed 046573 800 pounds: For continuously at a control of coccidiosis rate of 350 mg caused by Eimeria chlortetracycline bovis and E. zuernii; per head per day and for control of and 1 mg lasalocid bacterial pneumonia per 2.2 lb body associated with weight per day shipping fever complex with a maximum of caused by Pasteurella 360 mg lasalocid spp. susceptible to per head per day.. chlortetracycline..(xxv) 30 to 181.8................ Chlortetracycline Cattle up to 800 Hand feed 046573 500 to 4000. pounds: For control of continuously for coccidiosis caused by not more than 5 Eimeria bovis and E. days to provide 10 zuernii; and for mg treatment of bacterial chlortetracycline enteritis caused by E. per lb body weight coli and bacterial per day and 1 mg pneumonia caused by P. lasalocid per 2.2 multocida organisms lb body weight per susceptible to day with a maximum chlortetracycline.. of 360 mg lasalocid per head per day..(xxvi) 30 to 600................. Chlortetracycline 25 1. Pasture cattle Hand feed 046573 to 700. (slaughter, stocker, continuously at a feeder cattle, and rate of 350 mg beef replacement chlortetracycline heifers): for and not less than increased rate of 60 mg or more than weight gain; and for 300 mg lasalocid control of bacterial per head daily in pneumonia associated at least 1 lb of with shipping fever feed. Intakes of complex caused by lasalocid in Pasteurella spp. excess of 200 mg/ susceptible to head/day have not chlortetracycline.. been shown to be more effective than 200 mg/head/ day.. .................... 2. Pasture cattle under Hand feed 046573 700 pounds (slaughter, continuously at a stocker, feeder rate of 350 mg cattle, and beef chlortetracycline replacement heifers): and not less than for increased rate of 60 mg or more than weight gain; and for 300 mg lasalocid control of active per head daily in infection of at least 1 lb of anaplasmosis caused by feed. Intakes of Anaplasma marginale lasalocid in susceptible to excess of 200 mg/ chlortetracycline.. head/day have not been shown to be more effective than 200 mg/head/ day..(xxvii) 30 to 600................ Chlortetracycline 25 Pasture cattle over 700 Hand feed 046573 to 1100. pounds (slaughter, continuously at a stocker, feeder rate of 0.5 mg cattle, and beef chlortetracycline replacement heifers): per lb body weight For increased rate of per day and not weight gain; and for less than 60 mg or control of control of more than 300 mg active infection of lasalocid per head anaplasmosis caused by daily in at least Anaplasma marginale 1 lb of feed. susceptible to Intakes of chlortetracycline.. lasalocid in excess of 200 mg/ head/day have not been shown to be more effective than 200 mg/head/ day..(xxviii) 30 to 600............... Chlortetracycline Pasture cattle Hand feed 046573 500 to 4000.. (slaughter, stocker, continuously for feeder cattle, and not more than 5 dairy and beef days to provide 10 replacement heifers): mg For increased rate of chlortetracycline weight gain; and for per lb body weight treatment of bacterial per day and not enteritis caused by E. less than 60 mg or coli and bacterial more than 300 mg pneumonia caused by P. lasalocid per head multocida organisms daily in at least susceptible to 1 lb of feed. chlortetracycline.. Intakes of lasalocid in excess of 200 mg/ head/day have not been shown to be more effective than 200 mg/head/ day..----------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------ Ingredient Percent International feed No.------------------------------------------------------------------------Defluorinated Phosphate (20.5 35.9 6-01-080 percent Calcium, 18.5 percent Phosphorus).Sodium Chloride (Salt)............ 20.0 6-04-152Calcium Carbonate (38 percent 18.0 6-01-069 Calcium).Cottonseed Meal................... 10.0 5-01-621Potassium Chloride................ 3.0 6-03-755Selenium Premix (0.02 percent 3.0 .......................... Selenium) \1\.Dried Cane Molasses............... 2.5 4-04-695Magnesium Sulfate................. 1.7 6-02-758Vitamin Premix \1\................ 1.4 ..........................Magnesium Oxide................... 1.2 6-02-756Potassium Sulfate................. 1.2 6-06-098Trace Mineral Premix \1\.......... 1.04 ..........................Bovatec Premix (68 grams per 1.06 .......................... pound).------------------------------------------------------------------------\1\ Content of this vitamin and trace mineral premixes may be varied; however, they should be comparable to those used by the firm for other free-choice feeds. Formulation modifications require FDA approval prior to marketing. Selenium must comply with § 573.920 of this chapter. Ethylenediamine dihydroiodide (EDDI) should comply with FDA Compliance Policy Guide Sec. 651.100 (CPG 7125.18).
------------------------------------------------------------------------ Ingredient Percent International feed No.------------------------------------------------------------------------Cane Molasses.................... 55.167 4-13-241Condensed Molasses Fermentation 24.0 N/A Solubles.50% Urea Solution (23% N)........ 12.0 N/AAmmonium Polyphosphate Solution.. 1.0 6-08-42Phosphoric Acid (54%)............ 3.0 6-03-707Xanthan Gum...................... 0.05 8-15-818Water............................ 4.0 N/ATrace Mineral Mix \1\............ 0.5 N/AVitamin Premix \1\............... 0.2 N/ABovatec Liquid 20 (90.8 gm/lb) 0.083 N/A \2\.------------------------------------------------------------------------\1\ Content of vitamin and trace mineral premixes may be varied; however, they should be comparable to those used for other free-choice liquid feeds. Formulation modifications require FDA approval prior to marketing. Selenium must comply with § 573.920 of this chapter. EDDI should comply with FDA Compliance Policy Guide Sec. 651.100 (CPG 7125.18).\2\ To provide 150 gm lasalocid per ton, use 1.652 lb (0.083%) of Bovatec Liquid 20 (90.8 gm/lb). If dry Bovatec-68 (68 gm/lb) is used, use 2.206 lbs per ton (0.111%), replacing molasses.
------------------------------------------------------------------------ Ingredient Percent International feed No.------------------------------------------------------------------------Monocalcium Phosphate (21% P)..... 57.70 6-01-082Salt.............................. 17.55 6-04-152Distillers Dried Grains w/Solubles 5.40 5-28-236Dried Cane Molasses (46% Sugars).. 5.20 4-04-695Potassium Chloride................ 4.90 6-03-755Trace Mineral/Vitamin Premix\1\... 3.35 ..........................Calcium Carbonate (38% Ca)........ 2.95 6-01-069Mineral Oil....................... 1.05 8-03-123Magnesium Oxide (58% Mg).......... 1.00 6-02-756Iron Oxide (52% Fe)............... 0.10 6-02-431Lasalocid Type A Medicated Article 0.80 .......................... (68 g per pound).------------------------------------------------------------------------\1\ Content of vitamin and trace mineral premixes may be varied. However, they should be comparable to those used for other free-choice loose mineral feeds. Formulation modifications require FDA approval prior to marketing. Selenium must comply with § 573.920 of this chapter. EDDI should comply with FDA Compliance Policy Guides Sec. 651.100 (CPG 7125.18).
