Title 21: Food and Drugs
PART 558—NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS
Subpart B—Specific New Animal Drugs for Use in Animal Feeds
Browse Previous |
Browse Next
§ 558.455 Oxytetracycline and neomycin.
(a) Specifications. Type A medicated articles containing oxytetracycline equivalent to 50 grams per pound (g/lb) oxytetracycline hydrochloride and 50 g/lb neomycin sulfate or oxytetracycline equivalent to 100 g/lb oxytetracycline hydrochloride and 100 g/lb neomycin sulfate.
(b) Sponsors. See No. 066104 in §510.600(c) of this chapter.
(c) Related tolerances. See §§556.430 and 556.500 of this chapter.
(d) Indications for use—(1) Chickens. It is used in feed as follows:
---------------------------------------------------------------------------------------------------------------- Oxytetracycline and neomycin sulfate amount in grams per ton of feed Indications for use Limitations Sponsors----------------------------------------------------------------------------------------------------------------(i) 10 to 50............................. Chickens: For increased rate Feed continuously; do not 066104 of weight gain and improved feed to chickens producing feed efficiency. eggs for human consumption.(ii) 100 to 200.......................... Chickens: For control of Feed continuously for 7 to 066104 infectious synovitis caused 14 days (d); do not feed to by Mycoplasma synoviae; chickens producing eggs for control of fowl cholera human consumption; in low caused by Pasteurella calcium feed, withdraw 3 d multocida susceptible to before slaughter. oxytetracycline.(iii) 400................................ Chickens: For control of Feed continuously for 7 to 066104 chronic respiratory disease 14 d; do not feed to (CRD) and air sac infection chickens producing eggs for caused by M. gallisepticum human consumption; in low and Escherichia coli calcium feeds, withdraw 3 d susceptible to before slaughter. oxytetracycline.(iv) 500................................. Chickens: For reduction of Feed continuously for 5 d; 066104 mortality due to air do not feed to chickens sacculitis (air-sac- producing eggs for human infection) caused by E. consumption; withdraw 24 coli susceptible to hours before slaughter; in oxytetracycline. low calcium feeds withdraw 3 d before slaughter.----------------------------------------------------------------------------------------------------------------
|
(2) Turkeys. It is used in feed as follows:
|
---------------------------------------------------------------------------------------------------------------- Oxytetracycline and neomycin sulfate amount Indications for use Limitations Sponsors----------------------------------------------------------------------------------------------------------------(i) 10 to 50 g/ton of feed............... Growing turkeys: For Feed continuously; do not 066104 increased rate of weight feed to turkeys producing gain and improved feed eggs for human consumption. efficiency.(ii) 100 g/ton of feed................... Turkeys: For control of Feed continuously for 7 to 066104 hexamitiasis caused by 14 d; do not feed to Hexamita meleagridis turkeys producing eggs for susceptible to human consumption. oxytetracycline.(iii) 200 g/ton of feed.................. Turkeys: For control of Feed continuously for 7 to 066104 infectious synovitis caused 14 d; withdraw 5 d before by M. synoviae susceptible slaughter; do not feed to to oxytetracycline. turkeys producing eggs for human consumption.(iv) To provide 25 mg/lb of body weight Turkeys: For control of Feed continuously for 7 to 066104 daily. complicating bacterial 14 d; withdraw 5 d before organisms associated with slaughter; do not feed to bluecomb (transmissible turkeys producing eggs for enteritis; coronaviral human consumption. enteritis) susceptible to oxytetracycline.----------------------------------------------------------------------------------------------------------------
|
(3) Swine. It is used in feed as follows:
|
---------------------------------------------------------------------------------------------------------------- Oxytetracycline and neomycin sulfate amount Indications for use Limitations Sponsor----------------------------------------------------------------------------------------------------------------(i) 10 to 50 g/ton of feed............... Swine: For increased rate of ............................ 066104 weight gain and improved feed efficiency.(ii) To provide 10 mg/lb of body weight 1. Swine: For treatment of Feed continuously for 7 to 066104 daily. bacterial enteritis caused 14 d; withdraw 5 d before by E. coli and Salmonella slaughter. choleraesuis and treatment of bacterial pneumonia caused by P. multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin. 2. Breeding swine: For Feed continuously for not 066104 control and treatment of more than 14 d; withdraw 5 leptospirosis (reducing the d before slaughter. incidence of abortion and shedding of leptospirae) caused by Leptospira pomona susceptible to oxytetracycline.----------------------------------------------------------------------------------------------------------------
|
(4) Cattle and sheep. It is used in feed as follows:
|
---------------------------------------------------------------------------------------------------------------- Oxytetracycline and neomycin sulfate amount Indications for use Limitations Sponsor----------------------------------------------------------------------------------------------------------------(i) 10 to 20 grams per ton of feed....... Sheep: For increased rate of ............................ 066104 weight gain and improved feed efficiency.(ii) To provide 0.05 to 0.1 mg/lb of body Calves (up to 250 lb): For Feed continuously; in milk 066104 weight daily.. increased rate of weight replacers or starter feed. gain and improved feed efficiency.(iii) To provide 10 mg/lb of body weight 1. Calves and beef and Feed continuously for 7 to 066104 daily. nonlactating dairy cattle: 14 d; in feed or milk For treatment of bacterial replacers. If symptoms enteritis caused by E. coli persist after using for 2 and bacterial pneumonia or 3 d, consult a (shipping fever complex) veterinarian. Treatment caused by P. multocida should continue 24 to 48 susceptible to hours beyond remission of oxytetracycline; treatment disease symptoms. A and control of withdrawal period has not colibacillosis (bacterial been established for use in enteritis) caused by E. preruminating calves. Do coli susceptible to not use in calves to be neomycin. processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 d before slaughter. 2. Calves (up to 250 lb): Feed continuously for 7 to 066104 For treatment of bacterial 14 d; in milk replacers or enteritis caused by E. coli starter feed. If symptoms susceptible to persist after using for 2 oxytetracycline; treatment or 3 d, consult a and control of veterinarian. Treatment colibacillosis (bacterial should continue 24 to 48 enteritis) caused by E. hours beyond remission of coli susceptible to disease symptoms. A neomycin. withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 d before slaughter. 3. Sheep: For treatment of Feed continuously for 7 to 066104 bacterial enteritis caused 14 d. If symptoms persist by E. coli and bacterial after using for 2 or 3 d, pneumonia caused by P. consult a veterinarian. multocida susceptible to Treatment should continue oxytetracycline; treatment 24 to 48 hours beyond and control of remission of disease colibacillosis (bacterial symptoms. Withdraw 5 d enteritis) caused by E. before slaughter. coli susceptible to neomycin.(iv) To provide 25 mg/head/day........... Calves (250 to 400 lb): For ............................ 066104 increased rate of weight gain and improved feed efficiency.(v) To provide 75 mg/head/day............ Growing cattle (over 400 ............................ 066104 lb): For increased rate of weight gain; improved feed efficiency, and reduction of liver condemnation due to liver abscesses.(vi) To provide 0.5 to 2.0 g/head/day.... Cattle: For prevention and Feed 3 to 5 d before and 066104 treatment of the early after arrival in feedlots. stages of shipping fever A withdrawal period has not complex. been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older.----------------------------------------------------------------------------------------------------------------
