42 C.F.R. § 81.21 Cancers requiring the use of NIOSH-IREP.
Title 42 - Public Health
(a) DOL will calculate probability of causation for all cancers, except chronic lymphocytic leukemia as provided under §81.30, using NIOSH-IREP. (b) Carcinoma in situ (ICD–9 codes 230–234), neoplasms of uncertain behavior (ICD–9 codes 235–238), and neoplasms of unspecified nature (ICD–9 code 239) are assumed to be malignant, for purposes of estimating probability of causation. (c) All secondary and unspecified cancers of the lymph node (ICD–9 code 196) shall be considered secondary cancers (cancers resulting from metastasis of cancer from a primary site). For claims identifying cancers of the lymph node, Table 1 in §81.23 provides guidance for assigning a primary site and calculating probability of causation using NIOSH-IREP.
Title 42: Public Health
PART 81—GUIDELINES FOR DETERMINING PROBABILITY OF CAUSATION UNDER THE ENERGY EMPLOYEES OCCUPATIONAL ILLNESS COMPENSATION PROGRAM ACT OF 2000
Subpart E—Guidelines To Estimate Probability of Causation
§ 81.21 Cancers requiring the use of NIOSH-IREP.

