21 C.F.R. Subpart B—General Purpose Food Additives
Title 21 - Food and Drugs
(a) Product. Acetic acid. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Adipic acid. (b) [Reserved] (c) Limitations, restrictions, or explanation. This substance is generally recognized as safe when used as a buffer and neutralizing agent in accordance with good manufacturing or feeding practice. (a) Product. Citric acid. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Hydrochloric acid. (b) [Reserved] (c) Limitations, restrictions, or explanation. This substance is generally recognized as safe when used as a buffer and neutralizing agent in accordance with good manufacturing or feeding practice. (a) Product. Lactic acid. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Malic acid. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Phosphoric acid. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Potassium acid tartrate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium acid pyrophosphate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Succinic acid. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sulfuric acid. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Tartaric acid. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Aluminum sulfate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Aluminum ammonium sulfate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Aluminum potassium sulfate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Aluminum sodium sulfate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Ammonium bicarbonate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Ammonium carbonate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Ammonium hydroxide. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Ammonium phosphate (mono- and dibasic). (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Ammonium sulfate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Bentonite. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Butane. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Calcium carbonate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Calcium chloride. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Calcium citrate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Calcium gluconate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Calcium hydroxide. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Calcium lactate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Calcium oxide. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Calcium phosphate (mono-, di-, and tribasic). (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Caramel. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Carbon dioxide. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Dextrans of average molecular weight below 100,000. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Glycerin. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Glyceryl monostearate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Helium. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Hydrogen peroxide. (b) [Reserved] (c) Limitations, restrictions, or explanation. This substance is generally recognized as safe when used as a bleaching agent in accordance with good manufacturing or feeding practice. (a) Product. Lecithin. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Magnesium carbonate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Magnesium hydroxide. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Magnesium oxide. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. U.S.P. methylcellulose, except that the methoxy content shall not be less than 27.5 percent and not more than 31.5 percent on a dry-weight basis. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Monoammonium glutamate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Monopotassium glutamate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Nitrogen. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Papain. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Potassium bicarbonate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Potassium carbonate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Potassium citrate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Potassium hydroxide. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Potassium sulfate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Propane. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Propylene glycol. (b) Conditions of use. This substance is generally recognized as safe (except in cat food) when used in accordance with good manufacturing or feeding practice. [41 FR 38657, Sept. 10, 1976, as amended at 61 FR 19544, May 2, 1996] (a) Product. Rennet (rennin). (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Silica aerogel as a finely powdered microcellular silica foam having a minimum silica content of 89.5 percent. (b) [Reserved] (c) Limitations, restrictions, or explanation. This substance is generally recognized as safe when used as a component of antifoaming agents in accordance with good manufacturing or feeding practice. (a) Product. Sodium acetate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium bicarbonate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium carbonate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium carboxymethyl- cellulose is the sodium salt of carboxymethylcellulose not less than 99.5 percent on a dry-weight basis, with maximum substitution of 0.95 carboxymethyl groups per anhydroglucose unit, and with a minimum viscosity of 25 centipoises for 2 percent by weight aqueous solution at 25 °C. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium caseinate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium citrate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium hydroxide. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium pectinate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium phosphate (mono-, di-, and tribasic). (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium aluminum phosphate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium sesquicarbonate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium potassium tartrate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Sodium tripolyphosphate. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Triacetin (glyceryl triacetate). (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Beeswax (yellow wax). (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Bleached beeswax (white wax). (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice. (a) Product. Carnauba wax. (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Title 21: Food and Drugs
PART 582—SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart B—General Purpose Food Additives
§ 582.1005 Acetic acid.
§ 582.1009 Adipic acid.
§ 582.1033 Citric acid.
§ 582.1057 Hydrochloric acid.
§ 582.1061 Lactic acid.
§ 582.1069 Malic acid.
§ 582.1073 Phosphoric acid.
§ 582.1077 Potassium acid tartrate.
§ 582.1087 Sodium acid pyrophosphate.
§ 582.1091 Succinic acid.
§ 582.1095 Sulfuric acid.
§ 582.1099 Tartaric acid.
§ 582.1125 Aluminum sulfate.
§ 582.1127 Aluminum ammonium sulfate.
§ 582.1129 Aluminum potassium sulfate.
§ 582.1131 Aluminum sodium sulfate.
§ 582.1135 Ammonium bicarbonate.
§ 582.1137 Ammonium carbonate.
§ 582.1139 Ammonium hydroxide.
§ 582.1141 Ammonium phosphate.
§ 582.1143 Ammonium sulfate.
§ 582.1155 Bentonite.
§ 582.1165 Butane.
§ 582.1191 Calcium carbonate.
§ 582.1193 Calcium chloride.
§ 582.1195 Calcium citrate.
§ 582.1199 Calcium gluconate.
§ 582.1205 Calcium hydroxide.
§ 582.1207 Calcium lactate.
§ 582.1210 Calcium oxide.
§ 582.1217 Calcium phosphate.
§ 582.1235 Caramel.
§ 582.1240 Carbon dioxide.
§ 582.1275 Dextrans.
§ 582.1320 Glycerin.
§ 582.1324 Glyceryl monostearate.
§ 582.1355 Helium.
§ 582.1366 Hydrogen peroxide.
§ 582.1400 Lecithin.
§ 582.1425 Magnesium carbonate.
§ 582.1428 Magnesium hydroxide.
§ 582.1431 Magnesium oxide.
§ 582.1480 Methylcellulose.
§ 582.1500 Monoammonium glutamate.
§ 582.1516 Monopotassium glutamate.
§ 582.1540 Nitrogen.
§ 582.1585 Papain.
§ 582.1613 Potassium bicarbonate.
§ 582.1619 Potassium carbonate.
§ 582.1625 Potassium citrate.
§ 582.1631 Potassium hydroxide.
§ 582.1643 Potassium sulfate.
§ 582.1655 Propane.
§ 582.1666 Propylene glycol.
§ 582.1685 Rennet.
§ 582.1711 Silica aerogel.
§ 582.1721 Sodium acetate.
§ 582.1736 Sodium bicarbonate.
§ 582.1742 Sodium carbonate.
§ 582.1745 Sodium carboxymethylcellulose.
§ 582.1748 Sodium caseinate.
§ 582.1751 Sodium citrate.
§ 582.1763 Sodium hydroxide.
§ 582.1775 Sodium pectinate.
§ 582.1778 Sodium phosphate.
§ 582.1781 Sodium aluminum phosphate.
§ 582.1792 Sodium sesquicarbonate.
§ 582.1804 Sodium potassium tartrate.
§ 582.1810 Sodium tripolyphosphate.
§ 582.1901 Triacetin.
§ 582.1973 Beeswax.
§ 582.1975 Bleached beeswax.
§ 582.1978 Carnauba wax.
